The pig infectious gastroenteritis virus (TGEV) overview

Pathogenic characteristics

The pig infectious gastroenteritis virus (TGEV) belong to the coronavirus family, is an important pathogen causing viral diarrhea piglets. Virus particles round, oval, or polygon, the diameter of about 80 ~ 120 nm. TGEV for single strand RNA nucleic acid, its molecular weight is about 6.8 * 10 ^ 9 Dalton, has three major structural protein, N (tao), M (membrane protein) and S (ge). These proteins play an important role in the process of viral infections, including S protein is the major antigen of the virus, related to the neutralizing antibody generation.

epidemic

TGEV popular in many countries and regions in the world, especially in the temperate zone and frigid zone of more than 30 degrees north latitude regions. TGEV in China, mainly in winter and spring seasons, cold and in summer is relatively small. The disease for the first time the damage infected pigs, can cause pig disease, 100% of all ages and even vary with age, the age is smaller, the illness is heavier, the higher the mortality.

Route of transmission

TGEV transmission diversity, including direct contact with the transmission, the intake of food or water pollution substance, respiratory droplets spread, vertical transmission of viruses as well as environmental pollution and so on. Therefore, we suggest that take strict isolation measures and strengthen environmental disinfection to reduce the risk of transmission.

clinical signs and symptoms

TGEV infection after clinical symptoms include sudden vomiting and acute watery diarrhoea, manure yellow, weak green or white, sick pigs rapid dehydration, weight loss, and depression. For piglets, and its typical clinical manifestations include nursing to reduce or stop eating milk, tremor, thirst, angular, and death within 2 ~ 5 days. Into the swine, main show is anorexia or disappear, watery diarrhoea, and nursing sow lactation quantity will reduce or stop.

Pathological changes

TGEV infection caused by pathological changes mainly occurs in the stomach and small intestine. Stomach is full of curd piece, gastric mucosal hyperemia, sometimes have haemorrhage; Small intestinal wall thinning, intestinal yellow-green or pale liquid, mixed with air bubbles and curd piece. Lack of chyle in small intestine mesenteric lymphatic vessels.

Diagnostic methods

Diagnose TGEV infection rely mainly on virus isolation culture, electron microscope, serological detection and specific diagnostic techniques, such as rt-pcr and ELISA. In practice, the need for integrated analysis of the suspected cases, combined with clinical symptoms, history of epidemiological and laboratory testing results are confirmed.

Prevention and control measures

There is currently no specific medicine for the treatment of TGEV infection, treatment is generally recommended gastric disorder or decrease feed, feed add clean water or digestible, rehydration of pigs and rehydration salts and other measures. Due to the disease spread fast, once the disease is difficult to control, it is recommended that at the beginning of the outbreak of isolation and disinfection measures, and as far as possible use TGEV weak poison vaccine for prevention.

Summary

Above all, TGEV is a kind of important animal pathogens, is highly infectious and pathogenicity. Although there is no exact treatment, but through the reasonable prevention and control measures and vaccination can effectively reduce the influence of the herd of swine. In future research and practice, the need to further understand the basic characteristic of the virus, the transmission mechanism and the pathogenic mechanism, to develop more effective prevention and treatment strategies.